Activity Description
An IOM committee has been named to undertake a study to assess current relevant data and update as appropriate the DRIs for vitamin D and calcium. The review will include consideration of chronic and non-chronic disease indicators. The study will also incorporate, as appropriate, systematic evidence-based reviews of the literature and an assessment of potential indicators of adequacy and of excess intake. Indicators for adequacy and excess will be selected based on the strength and quality of the evidence and the demonstrated public health significance, taking into consideration sources of uncertainty in the evidence.
Specifically, in carrying out its work, the committee will:
(1) Review evidence on indicators of adequacy and on indicators of adverse effects from excess intake relevant to the general US and Canadian population, including for groups whose needs for or sensitivity to the nutrient may be affected by levels of skin pigmentation, and by particular conditions which are widespread in the population such as obesity or age-related chronic diseases. Special groups under medical care whose needs or sensitivities are affected by rare genetic disorders or diseases and their treatments will be excluded.
(2) Consider systematic evidenced-based reviews including those made available by the sponsors as well as others and carefully document the approach used by the committee to carry out any of its own literature reviews.
(3) Regarding selection of indicators upon which to base DRI values for adequate intake, give priority to selecting indicators of adequacy for the various age, gender, and lifestage groups that will allow for the determination of an Estimated Average Requirement.
(4) Regarding selection of indicators upon which to base DRI values for upper levels of intake, give priority to examining whether a critical adverse effect can be selected that will allow for the determination of a so-called benchmark intake.
(5) Update DRI values, as appropriate, using a risk assessment approach that includes (i) identification of indicators of adequacy and hazard, (ii) selection of the indicators of adequacy and the critical adverse effect, (iii) intake-response assessment, (iv) dietary intake assessment, and (v) risk characterization.
(6) Identify research gaps to address the uncertainties identified in the process of deriving the reference values and evaluating their public health implications.
Project Timeline
This is a 24 month study. The committee's report is expected to be publicly released by May 2010.
Meetings
The first meeting of the committee was held March 26-27, 2009 in Washington, DC. This meeting included an open session during which the study sponsors presented their perspectives to the committee.
The second committee meeting was held August 4-5, 2009 in Washington, DC. This meeting included an Information-Gathering Workshop on August 4, 2009.
The third committee meeting was held September 9-10, 2009 in Washington, DC. This meeting was a closed meeting.
The fourth committee meeting was held October 22-23, 2009 in Washington, DC. This meeting was a closed meeting, with an open session to address national survey design held on October 22, 2009.
The remaining committee meetings are now scheduled for: November 19-20, 2009, and January 5-6, 2010. At this point in time, an open session will be held on November 19, 2009 and the remaining meetings are scheduled to be closed meetings.
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