Microbial Evolution and co-Adaptation—A Workshop in Honor of Joshua Lederberg
Keck Building, 500 Fifth Street, NW – Room 100
Washington, DC
May 20 & 21, 2008
AGENDA

Day 1: Tuesday, May 20, 2008

9:00 – 9:30:  Registration and continental breakfast

9:30 – 9:45:  Welcoming Remarks: David Relman, M.D., Chair, and Peggy Hamburg, M.D., Vice-Chair, Forum on Microbial Threats  

9:45 – 10:45: Reflections on the Life and Scientific Legacies of Josh Lederberg
Moderator: Peggy Hamburg

David A. Hamburg, M.D.,  President Emeritus, Carnegie Corporation (NY)
Stephen S. Morse, Ph.D, Columbia University

10:45 – 11:15: Discussion

11:15 – 11:30:  BREAK

11:30 – 12:30: LUNCH

Session I: The microbiome and co-evolution
Moderator:  Jo Handelsman

12:30 – 1:00: Evolutionary and ecological processes that shape natural microbial communities
Jill Banfield, Ph.D., University of California, Berkeley

1:00 – 1:30:  Plant-Microbe Symbioses: the Good, the Bad and the Cheater!
Jean-Michel Ané, Ph.D., University of Wisconsin, Madison

1:30 – 2:00:   The experimental deciphering of the complex molecular dialogue between host and bacterial symbiont
Margaret McFall-Ngai, Ph.D., University of Wisconsin

2:00 – 2:30:  War and Peace: Humans and their Microbiome
David Relman, M.D., Stanford University

2:30 – 3:15:  Discussion of Session I

3:15 – 3:30:  BREAK

Session II: Microbial evolution and the emergence of virulence
Moderator:  P. Frederick Sparling

3:30 – 4:00:  A Schizophrenic View of Bacterial Pathogenicity
Stanley Falkow, Ph.D., Stanford University

4:00 – 4:30:   Recent Evolution in Invasive Salmonellosis
Gordon Dougan, Ph.D., The Sanger Institute

4:30 – 5:00:  Whole genome analysis of pathogen evolution
Julian Parkhill, Ph.D., The Sanger Institute

5:00 – 5:30:  The evolution of virulence in bacteria and viruses: an opinionated rant 
Bruce Levin, Ph.D., Emory University

5:30 – 6:00:  Discussion of Session II

6:15:         Adjourn—Day 1

7:00 – 9:00:  Dinner with speakers and Forum members and continuing discussion of Day 1
 

Day 2: Wednesday, May 21, 2008

8:30 – 9:00:  Continental breakfast

9:00 – 9:15:  Summary of Day 1, David Relman

9:15 – 9:45:   Further reflections on Josh Lederberg’s Life and Legacies
Adel Mahmoud, M.D., Ph.D., Princeton University

Session III: Mechanisms of resistance
Moderator: Steven Brickner

9:45 – 10:15: Microbial Drug Resistance: An Old Problem that Requires New Solutions
Stanley N. Cohen, M.D., Stanford University

10:15 – 10:45: Antibiotic Resistance and the Future of Antibiotics
Julian Davies, Ph.D., University of British Columbia

10:45 – 11:00: BREAK

11:00 – 11:30: Expanding the resistance universe with metagenomics
Jo Handelsman, Ph.D., University of Wisconsin, Madison

11:30 – 12:15: Discussion of Session III

12:15 – 1:00:   LUNCH

Session IV: Anticipation of future emerging infectious diseases—Is the past, prologue?
Moderator:  Stanley Lemon

1:00 – 1:30:  Emerging Infections: Condemned to Repeat?
Stephen S. Morse, Ph.D., Columbia University

1:30 – 2:00:  Can we predict future trends in Disease Emergence?
Peter Daszak, Ph.D., Consortium for Conservation Medicine, Wildlife Trust

2:00 – 2:30:   Pathogen emergence: ecology or evolution?
Mark Woolhouse, Ph.D., University of Edinburgh

2:30 – 3:00:  Genomic evolvability and the origin of novelty
Jonathan Eisen, Ph.D., UC Davis

3:00 – 3:30:   Discussion of Session IV

3:30 – 4:00:   Open discussion Wrap-up

4:00:           Adjourn